4 questions about COVID-19 vaccines and bivalent boosters, answered – MD Anderson Cancer Center

Log in to our secure, personalized website to manage your care (formerly myMDAnderson).
If you are ready to make an appointment, select a button on the right. If you have questions about MD Anderson’s appointment process, our information page may be the best place to start.
Find information and resources for current and returning patients.
Learn about clinical trials at MD Anderson and search our database for open studies.
The Lyda Hill Cancer Prevention Center provides cancer risk assessment, screening and diagnostic services.
Your gift will help support our mission to end cancer and make a difference in the lives of our patients.
Our personalized portal helps you refer your patients and communicate with their MD Anderson care team.
As part of our mission to eliminate cancer, MD Anderson researchers conduct hundreds of clinical trials to test new treatments for both common and rare cancers.
Choose from 12 allied health programs at School of Health Professions.
Learn about our graduate medical education residency and fellowship opportunities.
September 22, 2022
BY Jacqueline Mason
Last updated on Oct. 13, 2022
You’ve been vaccinated for COVID-19, but is it time for your next booster? Which type of booster should you get, and is there an age limit? What if you’ve recently been infected with the SARS CoV-2 virus that causes COVID-19? And let’s not forget it’s flu vaccination season. Can you get the COVID-19 and flu vaccinations at the same time?
Use these answers from Chief Infection Control Officer Roy Chemaly M.D., and Ann Klopp, M.D., Ph.D., medical director for MD Anderson’s COVID-19 vaccine clinics, to help you decide when and how to schedule your vaccinations.
Am I due for a COVID-19 booster?
Recently, the Food and Drug Administration (FDA) and Centers for Disease Control and Prevention (CDC) authorized updated, bivalent formulations of the Pfizer and Moderna COVID-19 vaccines for booster doses in the U.S. This bivalent booster replaces the original formulation of the booster vaccine.
That means the bivalent boosters are now the only type of boosters you can get if you are age 5 or older. The good news is the updated bivalent boosters provide the best available protection against the virus circulating most in the U.S. right now, the BA.5 Omicron subvariant.
The previous booster recommendations considered older age, immunocompromised status, and recommended time intervals between the first and second boosters. But these no longer apply. As long as you are age 5 or older, you are eligible to receive the bivalent booster if it has been at least two months since your last COVID-19 booster or primary series vaccination.
You can use the CDC’s schedule for staying up-to-date with your COVID-19 vaccinations.
Should I wait to be vaccinated if I’ve recently had COVID-19?
If you recently recovered from COVID-19, the CDC says you may consider waiting 3 months to be vaccinated from when your symptoms started or, if you had no symptoms, when you first received a positive test. That’s because reinfection may be less likely in the weeks after infection. It depends, however, on personal risk factors such as your risk of severe disease should you get reinfected, the level of COVID-19 in your community, and the transmissibility of the current COVID-19 variant causing infections.
It’s best to follow CDC guidelines for vaccination if you are moderately or severely immunocompromised.
Is it better for me to get an additional primary dose or a booster?
When it comes to COVID-19 vaccines, additional primary doses and boosters are not interchangeable. People who are moderately or severely immunocompromised need an additional primary dose as part of the primary vaccine series. This dose should be administered within a few weeks of the second dose of your primary series, depending on which vaccine product you received (e.g., Pfizer or Moderna). Since it is part of the primary series, it is the same monovalent vaccine formulation as the first two doses of your primary series.
Conversely, all COVID-19 booster vaccinations now are with the updated, bivalent formulations of the Pfizer or Moderna COVID-19 vaccines. So, if you need a booster, you’ll get the bivalent COVID-19 vaccine, regardless of whether you’ve had a booster dose before.
Follow the CDC’s COVID-19 Vaccination Schedule to know when you are eligible for your next dose or use the CDC’s Booster Tool to know when it is time for your first or next booster. If you are moderately or severely immunocompromised, be sure to look at the CDC’s specific vaccine booster recommendations for you.
Can I get my COVID-19 and flu vaccinations at the same time?
Yes, but it also depends on your personal circumstances. For most people, the CDC says it is safe to get your COVID-19 and flu vaccinations at the same visit as long as the injections are at least 1 inch apart.
However, there are additional considerations for those receiving a COVID-19 vaccine and another type of vaccination like a vaccine to protect against monkeypox. Also, some pharmacies in the community are requiring people who are immunocompromised to space out their COVID-19 and flu vaccinations by a few weeks to support the immune system’s response to the vaccinations.
If you’re a patient at MD Anderson, you can schedule your COVID-19 vaccine via MyChart.
Related stories
Our patients depend on blood and platelet donations.

© 2022 The University of Texas MD Anderson Cancer Center