As Covid Evolves in Long-Term Infections It May Become More Harmful, Study Says – Bloomberg

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A South African laboratory study using Covid-19 samples from an immunosupressed individual over six months showed that the virus evolved to become more pathogenic, indicating that a new variant could cause worse illness than the current predominant omicron strain. 
The research, conducted by the same laboratory that was to first test the omicron strain against vaccines last year, used samples from a person infected with HIV. The virus initially caused the same level of cell fusion and death as the omicron BA.1 strain, but as it evolved those levels rose to become similar to the first version of the coronavirus identified in Wuhan in China.