By American Heart Association News
The risk of developing myocarditis – an inflammation of the heart muscle – following a booster dose of the Pfizer COVID-19 vaccine is low, according to new research from Israel.
When vaccine-related myocarditis does occur, cases are typically mild, according to the study published Tuesday in the American Heart Association journal Circulation. It found the risk was highest among teen boys and young men.
“It is important to understand the connections between this rare heart condition and COVID-19 vaccines so we can monitor the prevalence of myocarditis and pay extra attention to those who are most at risk,” lead study author Dr. Dror Mevorach said in a news release. He is a professor of medicine and head of the Immunology-Rheumatology Institution at Hadassah Ein Karem Medical Center in Jerusalem and chairman of the Israeli Ministry of Health Committee for Identifying Myocarditis as an Adverse Effect of mRNA Vaccines.
Myocarditis is an inflammation of the middle layer of the wall of the heart muscle, called the myocardium. It can be triggered by a viral infection and can weaken the heart muscle and the heart’s electrical system, which makes it harder for the heart to beat normally. The condition can resolve on its own or with treatment, but also can cause lasting damage to the heart.
Previous research from public health agencies around the world, including the U.S. Centers for Disease Control and Prevention, has shown a potential increased risk of myocarditis following an mRNA COVID-19 vaccine. A recent study published by the Ministry of Health in Israel found a low incidence of myocarditis after a first and second dose of Pfizer’s vaccine. But because risk was highest among young men and teen boys who had a second dose of the vaccine, researchers were concerned about the potential effect a third dose, the booster dose.
In the new study, researchers analyzed health data for people who developed myocarditis following a third dose of the Pfizer vaccine, which was given to nearly 4 million Israeli adults between July 31 and Nov. 5, 2021. Within the first 30 days of receiving the booster, there were 35 reported cases of myocarditis. An additional 56 cases were reported after 30 days. Of those, 28 cases were confirmed or considered probable, and 18 of those occurred within a week of the booster being given.
All 28 cases were considered mild. Patients recovered after spending an average of three to four days in the hospital. Across all ages, the risk of developing vaccine-related myocarditis was nine times higher for men than women. Males ages 16-19 faced the highest risk, with young men ages 20-24 having the second-highest risk.
The risk of developing myocarditis among males ages 16-19 after a third dose was about 1 in 15,000. Other research shows COVID-19 infection poses a higher risk for myocarditis than vaccines.
The risk for developing myocarditis was lower following a booster than following a second dose of the vaccine, the researchers reported.
Mevorach suggested two possible reasons for this. As a medical precaution, people who developed myocarditis after the second COVID-19 vaccine dose did not receive a third dose. Also, timing may be a factor. The first and second doses are administered approximately three weeks apart, but the time between a second dose and a booster was about 20 to 24 weeks.
Researchers don’t know why young men and teenage boys are at higher risk for myocarditis from a COVID-19 vaccine and believe further investigation is needed.
If you have questions or comments about this American Heart Association News story, please email [email protected].
American Heart Association News covers heart disease, stroke and related health issues. Not all views expressed in American Heart Association News stories reflect the official position of the American Heart Association. Statements, conclusions, accuracy and reliability of studies published in American Heart Association scientific journals or presented at American Heart Association scientific meetings are solely those of the study authors and do not necessarily reflect the American Heart Association’s official guidance, policies or positions.
Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved. Permission is granted, at no cost and without need for further request, for individuals, media outlets, and non-commercial education and awareness efforts to link to, quote, excerpt or reprint from these stories in any medium as long as no text is altered and proper attribution is made to American Heart Association News.
HEALTH CARE DISCLAIMER: This site and its services do not constitute the practice of medical advice, diagnosis or treatment. Always talk to your health care provider for diagnosis and treatment, including your specific medical needs. If you have or suspect that you have a medical problem or condition, please contact a qualified health care professional immediately. If you are in the United States and experiencing a medical emergency, call 911 or call for emergency medical help immediately.
*All health/medical information on this website has been reviewed and approved by the American Heart Association, based on scientific research and American Heart Association guidelines. Find more information on our content editorial process.
7272 Greenville Ave.
Dallas, TX 75231
Monday – Friday: 7 a.m. – 7 p.m. CT
Saturday: 9 a.m. – 5 p.m. CT
Closed on Sundays
Tax Identification Number
©2022 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.
The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress ™ DHHS, Go Red ™ AHA ; National Wear Red Day® is a registered trademark.
This link is provided for convenience only and is not an endorsement of either the linked-to entity or any product or service.